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Dr Arya Gupta

Senior Lecturer

Arya (pronounced R-Joe) is a molecular microbiologist, with research experience and expertise in characterising mechanisms of antimicrobial resistance (AMR), AMR transfer in methicillin resistant Staphylococcus aureus, novel drug targets and pre-clinical evaluation of novel antibacterial compounds.

After completing his BSc in Microbiology at St. Xavier's College, Kolkata, India, Arya moved to the UK to pursue a MSc in Bioscience (Infection and Immunity) at the University of Leeds. After successfully completing the degree, he moved back to Kolkata for a year, only to come back to the University of Leeds (2013) to work as a research assistant in the School of Molecular and Cellular Biology before starting his PhD in June that year. His project focussed on the pre-clinical evaluation of potential inhibitors of aminoacyl-tRNA synthetase inhibitors in E. coli and S. aureus.

After completing his PhD (2017), Arya started working at St. George’s University of London as a Postdoctoral Research Assistant in the Institute of Infection and Immunity. During his time he designed a reliable in vitro experimental evolution model to assess antimicrobial resistance gene transfer in clinical MRSA. The assay developed has the potential to be implemented with different model organisms to elucidate exchange of resistance markers. At St George's, he also formulated an in vitro assay to assess competition between nasal microbiota and MRSA; and how antibiotics such as mupirocin might change this dynamic interaction.

In 2020, Arya moved to University of Kent for his second postdoc where his project looked at investigating and identifying novel combinatorial therapies to treat bacterial infections in cancer patients by targeting DNA Repair. He also developed and optimised a FRET based assay to study drug target interactions. 2022 saw him move back to University of Leeds where he took up the role of a Knowledge Transfer Partnership Associate on project primarily aimed at developing a 2-stage kit to test for microbial contamination in aviation fuel.

Since 2021, Arya has also been working pro bono as a scientific consultant for PHappi, a start-up focused on Femcare - particularly a novel way to treat UTIs.

In 2023, Arya was appointed as Senior Lecturer in Biomedical Sciences at Leeds Beckett University.

Current Teaching

Microbial World
Medical & Environmental Microbiology
Public Health Epidemiology
Enterprise Biomedical Science

Research Interests

Arya's research interest lies in infectious diseases and public health. Throughout his career, he has collaborated with a diverse, multi-disciplinary group of colleagues and his role with PHappi highlights his dedication to innovation in the female health field.

Arya's key research focus is to identify novel treatment regimes for bacterial infections by repurposing approved drugs to enhance the activity of antibiotics. He is also interested in better understanding the interaction between MRSA and the nasal microbiota and developing PoC tools for bacterial infections. He is also interested in antimicrobial resistance (AMR) transfer in ESKAPE pathogens; and is also keen on looking at AMR transfer between pathogen (primarily MRSA) and nasal commensal (which could also be translated to other microbiota settings).